Impact of adaptive thermogenesis in mice on the treatment of obesity

M Bastías-Pérez, S Zagmutt, MC Soler-Vázquez… - Cells, 2020 - mdpi.com
… , in mice this chronic cold temperature triggers an increase in their adaptive thermogenesis.
In this review, we aim to cover important aspects related to the adaptation of animals to room …

Recent advances in adaptive thermogenesis: potential implications for the treatment of obesity

SLJ Wijers, WHM Saris… - Obesity …, 2009 - Wiley Online Library
… In obese mice, it has been demonstrated that calcium cycling can be triggered with a …
Cold exposure in UCP-1 deficient mice showed an increase in Serca-2a expression, which …

Defective adaptive thermogenesis contributes to metabolic syndrome and liver steatosis in obese mice

L Poekes, V Legry, O Schakman… - Clinical …, 2017 - portlandpress.com
… Induction of endogenous BAT function had a significant therapeutic impact on obesity,
glucose tolerance and liver complications and is a potential new avenue for therapy of non-…

Effects of ambient temperature on adaptive thermogenesis during maintenance of reduced body weight in mice

Y Ravussin, CA LeDuc… - American Journal of …, 2012 - journals.physiology.org
… room temperature, leptin, and metabolic adaptation to weight reduction, we … obese and
Lep ob mice housed at both 22C and 30C. DIO mice were used as a model for human obesity

Dietary iron deficiency modulates adipocyte iron homeostasis, adaptive thermogenesis, and obesity in C57BL/6 mice

JS Yook, SS Thomas, AM Toney, M You… - The Journal of …, 2021 - academic.oup.com
… /6 mice. Our work demonstrated that dietary iron deficiency contributes to obesity by attenuating
adaptive thermogenesis. … to evaluate the impacts of dietary iron deficiency on obesity by …

Clinical significance of adaptive thermogenesis

GC Major, E Doucet, P Trayhurn, A Astrup… - … journal of obesity, 2007 - nature.com
… a role for adaptive thermogenesis in unsuccessful weight loss … As also discussed in this
paper, this ‘adaptive thermogenesis… vulnerable individuals, adaptive thermogenesis can be multi-…

[HTML][HTML] Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis

M Razzoli, A Frontini, A Gurney, E Mondini… - Molecular …, 2016 - Elsevier
… Here we demonstrated that the level of adaptive thermogenesis and the … -induced obesity
in mice in spite of similar level of hyperphagia, offering a key to interpret the dichotomous effect

Towards a molecular understanding of adaptive thermogenesis

BB Lowell, BM Spiegelman - Nature, 2000 - nature.com
… in many models of obesity, including leptin-deficient ob/ob mice 16 . Leptin … by the fact that
transgenic mice with toxigene-mediated … for this effect is unknown but could include effects on …

Adaptive thermogenesis in humans

M Rosenbaum, RL Leibel - International journal of obesity, 2010 - nature.com
… As illustrated by diet-induced obesity-prone and -resistant mouse strains, 2 as … adaptive
thermogenesis, this effect is more likely to be evident in obligatory than facultative thermogenesis

[HTML][HTML] Detection of thermogenesis in rodents in response to anti-obesity drugs and genetic modification

JRS Arch, P Trayhurn - Frontiers in Physiology, 2013 - frontiersin.org
… We have suggested that the anti-obesity effect of ZAG may be … adaptive thermogenesis is
in brown adipose tissue find that much of the thermogenic response to noradrenaline in mice